血红素加氧酶-1与神经退行性疾病的研究进展
Research progress of heme oxygenase-1 in neurodegenerative diseases
杨帅天 1费俊尧 1徐诺 1殷永康 1蒋余嘉 1聂政2
作者信息
- 1. 成都医学院2020级临床医学专业,四川 成都 610500
- 2. 成都医学院人体解剖学教研室/发育与再生四川省重点实验室,四川 成都 610500
- 折叠
摘要
血红素加氧酶-1(HO-1)是一种诱导性血红素加氧酶,是血红素分解反应的催化酶,能将血红素分解为CO、胆绿素和Fe2+等.HO-1及其代谢产物在人体中具有抗炎、抗氧化、抗凋亡等作用,在阿尔茨海默病、帕金森病、肌萎缩侧索硬化、亨廷顿舞蹈症等神经退行性疾病中具有重要作用.本文将从HO-1的生成、分布及基因结构,产物的生物学特性,在神经退行性疾病中的作用及机制等方面进行综述,以期为HO-1的临床应用提供理论依据.
Abstract
Heme oxygenase-1(HO-1)is an inducible heme oxygenase and a catalytic enzyme for heme decomposition reactions,which can catalyze the heme decomposition into CO,biliverdin and Fe2+.HO-1 and its metabolites have anti-inflammatory,antioxidant and anti-apoptotic effects in human body,and play an important role in neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and Huntington's disease.This article will review the production,distribution,and gene structure of HO-1,the biological characteristics of its metabolites,and the role and mechanism of HO-1 in neurodegenerative diseases,in order to provide a theoretical basis for the clinical application of HO-1.
关键词
血红素加氧酶-1/神经退行性疾病/生物学特性/阿尔茨海默病/帕金森病/肌萎缩侧索硬化Key words
heme oxygenase-1/neurodegenerative diseases/biological characteristics/Alzheimer's disease/Parkinson's disease/amyotrophic lateral sclerosis引用本文复制引用
基金项目
四川省大学生创新创业训练计划项目(S202213705083)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据