铅对线粒体毒性机制的研究进展
Research progress on the toxic mechanism of Pb to mitochondria
田嘉成 1许商成1
作者信息
- 1. 南京医科大学公共卫生学院,江苏 南京 211100
- 折叠
摘要
铅对多种器官组织都具有毒性作用.尽管含铅汽油和油漆已被禁止使用,但环境中仍残留大量的铅,对公共卫生安全构成极大的威胁.因此,迫切需要明确铅毒性的作用机理.已有大量研究表明,线粒体是铅的敏感靶标.铅不仅会引起线粒体氧化应激和能量代谢障碍,还会引起线粒体功能障碍从而导致炎症、凋亡、自噬等紊乱.因此,线粒体功能障碍是铅毒性的重要机制.本文就铅对线粒体膜通透性、线粒体自噬、线粒体融合和分裂的影响的研究进展进行综述,以期为铅中毒的进一步机制研究和干预治疗提供参考依据.
Abstract
Pb exhibits toxic effects on various organ and tissues.Despite the prohibition of leaded gasoline and paint,a considerable amount of Pb remains in the environment,posing a significant threat to public health and safety.Therefore,it is urgent to clarify the mechanisms of Pb toxicity.Numerous studies have indicated that mitochondria are the sensitive targets of Pb.Pb can not only induce mitochondrial oxidative stress and energy metabolism disorder,but also cause mitochondrial dysfunction,leading to inflammation,apoptosis,autophagy,and other disorders.Therefore,mitochondrial dysfunction is a critical mechanism of Pb toxicity.This article reviews the research progress in the effects of Pb on mitochondrial membrane permeability,mitochondrial autophagy,mitochondrial fusion and fission,aiming to provide a reference for future mechanism studies and intervention treatment of Pb poisoning.
关键词
铅/线粒体膜通透性/线粒体自噬/线粒体融合和分裂Key words
Pb/mitochondrial membrane permeability/mitochondrial autophagy/mitochondrial fusion and fission引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据