目的 探讨F4.8可视化穿刺辅助微通道经皮肾镜碎石术(mPCNL)治疗肾盏憩室结石患者的应用效果.方法 选取2020年1月至2023年1月合肥市第一人民医院收治的肾盏憩室结石患者86例,按照随机数字表法分为观察组和常规组,每组43例.常规组患者行mPCNL,观察组患者行F4.8可视化穿刺辅助mPCNL.比较2组患者术后即刻及术后4周的结石清除率、手术及术后恢复情况、并发症及手术前后创伤应激指标[血清皮质醇(Cor)、去甲肾上腺素(NE)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]、肾叶间动脉血流动力学指标[收缩期峰流速(Vmax)、舒张末期流速(EDV)、阻力指数(RI)]、肾功能指标[尿液中肾损伤分子-1(KIM-1)、24 h尿蛋白定量(24 h Upro)、血尿素氮(BUN)、血肌酐(Scr)]水平.结果 观察组患者术后即刻结石清除率高于常规组,术中失血量少于常规组,手术时间、术后下床活动时间、留置肾造瘘管时间、住院时间短于常规组,差异均有统计学意义(P<0.05).2组患者术后1 d、3 d的血清Cor、NE、CRP、IL-6水平较术前升高(P<0.05),观察组术后1 d、3 d的血清Cor、NE、CRP、IL-6水平均低于常规组(P<0.05).观察组患者术后1 d的肾叶间动脉Vmax、EDV较术前降低(P<0.05),RI较术前升高(P<0.05);常规组患者术后1 d、3 d的肾叶间动脉Vmax、EDV较术前降低(P<0.05),RI较术前升高(P<0.05);观察组术后1 d、3 d的肾叶间动脉Vmax、EDV高于常规组,RI低于常规组,差异均有统计学意义(P<0.05).2组患者术后7 d尿液中KIM-1、24 h Upro、BUN、Scr水平较术前降低,且观察组低于常规组,差异均有统计学意义(P<0.05).2组并发症发生率比较,差异无统计学意义(P>0.05).结论 F4.8可视化穿刺辅助mPCNL治疗肾盏憩室结石能提高手术效果,减轻手术创伤应激,促进肾功能恢复.
Application of F4.8 visualized puncture assisted microchannel percutaneous nephrolithotomy in the treatment of calyceal diverticular calculus
Objective To investigate the application effect of F4.8 visualized puncture assisted microchannel percutaneous nephroli-thotomy(mPCNL)in the treatment of patients with calyceal diverticular calculus.Methods A total of 86 patients with calyceal diverticular calculus from January 2020 to January 2023 in Hefei First People's Hospital were selected and divided into the observation group and the conventional group according to random number table method,with 43 cases in each group.Patients in the conventional group were given mPCNL,while patients in the observation group were given F4.8 visualized puncture assisted mPCNL.The stone clearance rate immediately after surgery and 4 weeks after surgery,surgery and postoperative recovery,complications,as well as pre-and post-operative trauma stress indicators[serum cortisol(Cor),norepinephrine(NE),C-reactive protein(CRP),interleukin-6(IL-6)],interlobar renal artery hemodynamic indicators[peak systolic velocity(Vmax),end diastolic velocity(EDV),resistance index(RI)],and renal function indicators[urine kidney injury molecule-1(KIM-1),24 h urinary protein quantitation(24 h Upro),blood urea nitrogen(BUN),serum creatinine(Scr)]were compared between the two groups.Results The stone clearance rate immediately after surgery in the observation group was higher than that in the conventional group,the intraoperative blood loss was less than that in the conventional group,and the operation time,postoperative ambulation time,indwelling nephrostomy tube time,and hospitalization time were shorter than those in the conventional group,and the differences were statistically significant(P<0.05).The serum levels of Cor,NE,CRP and IL-6 1 day and 3 days after surgery in the two groups were higher than those before operation(P<0.05),while the serum levels of Cor,NE,CRP and IL-6 1 day and 3 days after surgery in the observation group were lower than those in the conventional group(P<0.05).The Vmax and EDV of renal interlobar artery 1 day after surgery in the observation group decreased compared with those before operation(P<0.05),while RI increased(P<0.05).The Vmax and EDV of renal interlobar artery 1 day and 3 days after surgery in the conventional group decreased compared with those before operation(P<0.05),while RI increased(P<0.05).The Vmax and EDV of renal interlobar artery 1 day and 3 days after surgery in the observation group were higher than those in the conventional group,while RI was lower than that in the conventional group,and the differences were statistically significant(P<0.05).The levels of KIM-1,24 h Upro,BUN,and Scr of urine 7 days after surgery in both groups were lower than those before surgery,and those in the observation group were lower than those in the conventional group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of complication between the two groups(P>0.05).Conclusion F4.8 visualized puncture assisted mPCNL for the treatment of calyceal diverticular calculus can improve surgical effect,reduce surgical trauma stress,and promote renal function recovery.
万方数据
维普
