Snake venom is a complex mixture of bioactive proteins and polypeptides,including snake venom metalloproteinases,trypsin-like serine proteinases,PLA2 and C-type lectin,etc.Hemorrhage is the most distinctive aspect of viperid snakebite envenoming.The main culprits for hemorrhagic effect are zinc-dependent metalloproteinases (SVMPs).The SVMPs can directly hydrolyze basement membrane,extracellular matrix components,collagen and fibrinogen.In addition,the SVMPs can also induce cell apoptosis,promote leukocyte rolling and inhibit platelet aggregation.In this paper,we review the history and advancement of research on SVMPs in order to provide an update of the structure and bioactivity knowledge about SVMPs.
NETL
NSTL
万方数据
维普
