Combined Immunization Effect of Reassortant Avian Influenza Virus(H5+H7)Trivalent Vaccine with Newcastle Disease,Avian Influenza(Subtype H9)and Fowl Adenoviruses Disease(Group Ⅰ Serotype 4)Vaccine
In order to evaluate the combined immune effect of reassortant avian influenza virus(H5+H7)trivalent vaccine with Newcastle disease,avian influenza(subtype H9)and fowl adenoviruses disease(groupⅠserotype 4)vaccine,120 healthy commercial yellow-feather broilers of 11 days age were randomly divided into fourgroups,including mixed vaccines combined immunization group,point immunization group,and single vaccine immunization groups,respectively.Blood samples were collect-ed before immunization and at 14,21,28 and 35 days after immunization to detect the specific antibody levels in chicken serum.The safety,immune efficacy and dynamics of antibody of combined immunization with the two mixed vaccines were evaluated.The results showed that the physiological activities such as spirit status,appetite and respiration of chickens in each group were not abnormal within one week after immunization.In mixed vaccines combined immunization group,the titers of six pathogens an-tibodies increased at 14 days after immunization,reached the ideal level at 21 days after immunization,and the titers of antibodies were higher than 5 log2 at 28 days after immunization.The level of antibody and dynamics of antibody in mixed vaccines combined immunization group were consistent with the other groups.The results indicated that the safety and immune effect of the two kinds of avian influenza vaccines combined immunization after mixing were comparable to those of the single vaccine without interfer-ence,could reduce the stress in flocks and save labors,provided a reference for optimizing immune program of poultry farms.
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