Synergistic Pathogenic Effects of Early Co-infection of Avian Hepatitis E Virus and Chicken Infectious Anemia Virus in SPF Chicken
In order to investigate the pathogenicity of co-infection of avian hepatitis E virus(aHEV)and chicken infectious anemia virus(CIAV),the effect of their early co-infection were observed through various indicators such as body weight,mortality rate and organ index.The results showed that the co-infection group of aHEV and CIAV had the highest mortality rate and consistently had the lowest body weight at each time-point.The co-infection of aHEV and CIAV could significantly exacerbate liver enlargement and thymus atrophy,which could promote the replication of CIAV in liver,spleen,thymus,bursa of Fabricius and blood.And the co-infection of aHEV and CIAV also promoted the replication of aHEV in the above four organs and excreted viruses through the cloaca.The results indicated that a co-infection animal model of aHEV and CIAV was successfully constructed and confirmed the co-infection of aHEV and CIAV at early stage could exacerbate the pathogenicity and immune suppression to SPF chicken,suggesting the need to strengthen the detection and eradication of co-infection of aHEV and CIAV.
avian hepatitis E viruschicken infectious anemia virusco-infectionpathogenicityimmunosuppression
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