禽戊型肝炎病毒与鸡传染性贫血病毒早期共感染SPF鸡的致病性观察
Synergistic Pathogenic Effects of Early Co-infection of Avian Hepatitis E Virus and Chicken Infectious Anemia Virus in SPF Chicken
张煜朵 1张亚文 1王金金 1常爽 1王一新 1赵鹏1
作者信息
- 1. 山东农业大学动物科技学院(动物医学院),山东 泰安 271018;山东省人兽共患病重点实验室,山东 泰安 271018
- 折叠
摘要
为研究禽戊型肝炎病毒(aHEV)与鸡传染性贫血病毒(CIAV)早期共感染的致病性,试验将aHEV与CIAV人工感染SPF鸡胚或雏鸡后,通过检测体重、死亡率、器官指数等多项指标研究两者早期共感染对SPF鸡的影响.结果显示:aHEV和CIAV共感染组死亡率最高,且在各统计时间点共感染组体重始终最低;aHEV与CIAV的早期共感染可显著加重肝脏的肿大和胸腺的萎缩,可促进CIAV在肝脏、脾脏、胸腺、法氏囊以及血液中的复制,反之共感染也可促进aHEV在上述四种器官中的复制以及通过泄殖腔的排毒.研究表明,试验成功构建了aHEV与CIAV早期共感染动物模型,并证实其可加重对SPF鸡的致病性和免疫抑制,提示需要加强对aHEV与CIAV共感染的检测与净化.
Abstract
In order to investigate the pathogenicity of co-infection of avian hepatitis E virus(aHEV)and chicken infectious anemia virus(CIAV),the effect of their early co-infection were observed through various indicators such as body weight,mortality rate and organ index.The results showed that the co-infection group of aHEV and CIAV had the highest mortality rate and consistently had the lowest body weight at each time-point.The co-infection of aHEV and CIAV could significantly exacerbate liver enlargement and thymus atrophy,which could promote the replication of CIAV in liver,spleen,thymus,bursa of Fabricius and blood.And the co-infection of aHEV and CIAV also promoted the replication of aHEV in the above four organs and excreted viruses through the cloaca.The results indicated that a co-infection animal model of aHEV and CIAV was successfully constructed and confirmed the co-infection of aHEV and CIAV at early stage could exacerbate the pathogenicity and immune suppression to SPF chicken,suggesting the need to strengthen the detection and eradication of co-infection of aHEV and CIAV.
关键词
禽戊型肝炎病毒/鸡传染性贫血病毒/共感染/致病性/免疫抑制Key words
avian hepatitis E virus/chicken infectious anemia virus/co-infection/pathogenicity/immunosuppression引用本文复制引用
出版年
2025
NETL
NSTL
万方数据