In order to explore the purification effects of different disinfectants(povidone iodine and chlorine dioxide)on wastewater from medium to large-scale egg duck farms,the changes of chemical oxygen demand(COD),number of Escherichia coli,total number of bacteria,ammonia nitrogen(NH3-N),and pH value in the water were detected after 0(control group)2,8,26 and 32 h of disinfection.The results showed that compared with the control group(after 0 h of disinfection),the COD content,total bacterial count,pH value and the number of Escherichia coli were all significantly decreased after disinfection with povidone iodine for 2 to 32 h(P<0.01),and the NH3-N content was also significantly decreased after disinfection for 32 h(P<0.05).Similarly,after disinfection with chlorine dioxide for 2 to 32 h,the total number of bacteria,the number of Escherichia coli,and pH value were all significantly decreased(P<0.01),but the NH3-N content was significantly increased(P<0.01).Compared to povidone iodine,after disinfection with chlorine dioxide for 2 to 32 h,the total number of bacteria significantly decreased,and after disinfection for 8 h(P<0.05),the number of Escherichia coli significantly decreased(P<0.05).Compared with povidone iodine,using chlorine dioxide to purify wastewater could significantly reduce feeding costs.The results indicated that chlorine dioxide was a more optimal disinfectant choice breeding cost of laying duck farms and key indicators in breeding production(total number of bacteria and Escherichia coli).