Method and Application of Establishing Gene Edited Chicken
The chicken is an excellent model for the study of developmental biology,immunology and infectious diseases,as well as an important agricultural economic animal to meet people's needs for meat and eggs.In recent years,with the continuous growth of global chicken production and consumption,the poultry industry's demand for avian disease prevention and control,seed preservation and breeding has also increased.Therefore,researchers combined gene editing technology to prepare transgenic chickens or gene-edited chickens,so as to have a deeper understanding of chicken growth and development,immune and disease resistance mechanisms,and providing a solid theoretical basis for industrial practice.Due to the unique reproductive physiological characteristics of chickens,single-cell eggs cannot be obtained,and it is difficult to apply mammalian gene editing methods.Here,the advantages and disadvantages of the existing methods of preparing gene-edited chicken were summarized,the existing problems in the preparation process of gene-edited chickens were pointed out,which provided reference for the preparation of gene-edited chicken.
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