Objective To investigate the association between right atrial strain-area index(RASAI,the ratio of right atrial reservoir strain to right atrial area)and the prognosis of pulmonary arterial hypertension(PAH).Methods A total of 91 PAH patients who received treatment at Guangdong Provincial People's Hospital from October 2021 to April 2023 were included.Echocardiographic parameters,including right atrial strain and right atrial area,were measured.The association between the RASAI and PAH prognosis was analyzed.Results After a median follow-up of 17(12,26)months,19 adverse events occurred.Cox regression analysis revealed that for per unit increase in RASAI,the risk of adverse outcomes decreased by 40％(unadjusted model,HR 0.60,95％CI 0.40-0.91,P=0.016).This association remained statistically significant after multivariable adjustment(HR 0.50,95％CI 0.29-0.84,P=0.009).Results from tertile grouping and restricted cubic spline analysis further confirmed that RASAI has a dose-response relationship with adverse prognosis.Patients in the high RASAI group had significantly better prognosis than those in the low RASAI group(multivariable adjusted model,HR 0.21,95％CI 0.06-0.70,P=0.011).Conclusions The right atrial strain-area index is closely related to adverse prognosis and may serve as a potential indicator for therapeutic assessment and prognostic prediction.
关键词
右心房应变/右心房面积/肺动脉高压/预后
Key words
Right atrial strain/Right atrial area/Pulmonary arterial hypertension/Prognosis
维普
万方数据