Acute ST-segment elevation myocardial infarction is one of the most serious critical diseases of cardiovascular disease,with high morbidity and mortality,which is one of the major challenges facing emergency interventional physicians.At present,the mainstream strategy of emergency intervention is to insert drug-eluting stents into the site of acute vascular occlusion,so as to restore coronary blood flow supply,reduce the scope of myocardial infarction and improve prognosis.However,the implantation of drug-coated stents also brings a series of problems,such as acute stent thrombosis,restenosis in the stent,and no recurrence after stent implantation due to heavy thrombus load.In recent years,with the concept of"leave-nothing-behind strategy"deeply rooted in physicians'hearts,the application of drug-coated balloons is more and more extensive.At present,the application of drug-coated balloon in stent restenosis and small vessel disease has been widely recognized,but its efficacy in interventional therapy for acute ST-segment elevation myocardial infarction is still little studied.This paper mainly reviews the feasibility,safety and effectiveness of drug-coated balloon in interventional therapy for acute ST-segment elevation myocardial infarction at home and abroad.The aim is to guide the choice of emergency intervention strategy and improve the prognosis of patients.