Patent foramen ovale(PFO)is an important risk factor for cardiogenic stroke.With the rapid development of cardiac interventional techniques,PFO occluder has become the first choice for the treatment of PFO.The biocompatibility,mechanical stability of the occluder material and its adaptability to the patient's anatomical structure are key factors in determining the therapeutic effect.Remarkable progress has been made in its research.In the early stage,the occluder was mainly made of metal material.Although it has high sealing effect and operation convenience,there is potential risk of long-term retention in the body.In recent years,biodegradable materials have been widely used in the field of sealers,such sealers are made of biomedical polymer materials,implanted into the human body to play a temporary bridge role,guide self-tissue bioremediation,and gradually degrade into harmless substances discharged from the body,avoiding the long-term retention of metal sealers.This paper reviews the research progress of PFO occluder materials,including the application of non-degradable materials and biodegradable materials,and discusses the limitations of the current research and the possible development trend in the future,so as to provide reference for clinical application.
维普
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