Research progress on reverse genetics of coronavirus
Coronaviruses are rapidly evolving pathogens capable of infecting a wide range of animals and humans,causing mild to severe respiratory infections,and are widely prevalent globally,especially with the unprecedented SARS-CoV-2 outbreak in 2019,which has resulted in a severe public health crisis and significant economic losses to society,and an urgent need to deepen the understanding of coronavirus biology..Reverse genetics is a powerful platform for studying the structure and function of viral genomes,and has been widely applied to the study of viral replication and pathogenesis,characterization of protein function,development of attenuated vaccines,and screening of antiviral therapeutics.In this paper,we summarize the progress of coronaviruses and the coronavirus reverse genetics system and provide an outlook,which is expected to provide new insights for further basic research on coronavirus pathogenicity and prevention,as well as applied research on the construction of coronavirus vectors and the development of novel vaccines.
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