The diagnostic value of serum YKL-40 and SOCS3 for postoperative bacterial lung infection in non-small cell lung cancer patients
Objective To investigate the expression of serum chitinase-3-like protein 1(YKL-40)and suppressor of cytokine signaling 3(SOCS3)and their diagnostic value for postoperative bacterial lung infection in non-small cell lung cancer patients.Method In this study,87 patients with non-small cell lung cancer admitted to our hospital from January 2021 to December 2023 were grouped into infection group(n=42)and non-infection group(n=45)according to whether postoperative bacterial lung infection occurred.Enzyme-linked immunosorbent assay was used to measure the expression levels of serum YKL-40 and SOCS3.Spearman method was used to analyze the correlation between YKL-40 and SOCS3 with CPIS score and APACHE Ⅱ score.Logistic regression analysis was used to analyze the influencing factors of postoperative bacterial lung infection.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of YKL-40 and SOCS3 for postoperative bacterial lung infection in non-small cell lung cancer patients.Result There were great differences in CPIS score and APACHE Ⅱ score between the non-infection group and the infection group(P＜0.05).Compared with the non-infection group,the serum YKL-40 was highly expressed(P＜0.05)and SOCS3 was lowly expressed in infection group(P＜0.05).YKL-40 was positively correlated with CPIS score and APACHE Ⅱ score(P＜0.05),while SOCS3 was negatively correlated with CPIS score and APACHE Ⅱ score(P＜0.05).Serum YKL-40 was a risk factor for postoperative bacterial lung infection(P＜0.05),while SOCS3 was a protective factor(P＜0.05).The area under the curve of serum YKL-40 alone in the diagnosis of bacterial lung infection after non-small cell lung cancer surgery was 0.881,and the area under the curve of SOCS3 alone was 0.866.The area under the curve of the combined diagnosis of the two was 0.962,which was greatly larger than that of YKL-40(Z=1.969,P=0.049)and SOCS3(Z=2.144,P=0.032)alone.Conclusion Serum YKL-40 is increased and SOCS3 is decreased in patients with bacterial lung infection after non-small cell lung cancer surgery.The combination of the two has a high diagnostic value for bacterial lung infection after non-small cell lung cancer surgery.
non-small cell lung cancerbacterial lung infectionChitinase-3-like protein 1(YKL-40)suppressor of cytokine signaling 3(SOCS3)
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