Study on the correlation between intestinal bacterial distribution and cognitive function in elderly patients with cerebral infarction
Objective To investigate the relationship between intestinal bacterial distribution and cognitive dysfunction in elderly patients with cerebral infarction,aiming to provide new insights for the prevention and treatment of post-stroke cognitive impairment.Methods A total of 140 elderly patients with cerebral infarction undergoing thrombolytic therapy were enrolled in this study and followed up for 6 months.Based on the follow-up results,patients were divided into a cognitive impairment group(62 cases)and a cognitively normal group(78 cases).Basic information,laboratory test indicators(including Hs-CRP,Hcy,etc.),and the quantities of common intestinal bacteria(such as Escherichia coli,Enterococcus,Lactobacillus,Bifidobacterium,and Peptococcus)were collected and analyzed from both groups.Multivariate logistic regression analysis was performed to identify factors associated with cognitive dysfunction,and ROC curve analysis was used to evaluate the predictive value of each indicator for cognitive dysfunction.Results The levels of Hs-CRP(25.82 4.77 ng/L)and Hcy(23.12±5.53 μmol/L)were significantly higher in the cognitive impairment group than in the cognitively normal group(21.36±4.51 ng/L and 20.58±4.91 μmol/L,respectively;P＜0.05).The numbers of E.coli and Enterococcus were significantly higher,while those of Lactobacillus,Bifidobacterium,and Peptococcus were significantly lower in the cognitive impairment group compared to the cognitively normal group(P＜0.05).Multivariate logistic regression analysis revealed that high levels of Hs-CRP(OR=1.483),Hcy(OR=1.241),E.coli(OR=1.459),and Enterococcus(OR=1.776)were risk factors for cognitive dysfunction,while high numbers of Lactobacillus(OR=0.493),Bifidobacterium(OR=0.764),and Peptococcus(OR=0.548)were protective factors.ROC curve analysis indicated that Hs-CRP,Hcy,and intestinal bacterial counts,either alone or in combination,could effectively predict the occurrence of cognitive dysfunction,with the highest AUC(0.952)achieved when all indicators were combined.Conclusion There is a significant correlation between intestinal microbial distribution and cognitive dysfunction in elderly patients with cerebral infarction.Specifically,elevated levels of Hs-CRP and Hcy and changes in the quantities of specific intestinal bacteria may serve as important risk factors for cognitive dysfunction.
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