The diagnostic value of serum HBD-3 and LRG1 for urinary tract infections after minimally invasive surgery for uterine fibroids
Objective To investigate the diagnostic value of serum β-defendin-3(HBD-3)and leucine rich alpha-2-glycoprotein 1(LRG1)for urinary tract infections after minimally invasive surgery for uterine fibroids.Methods Eighty patients with urinary tract infections after minimally invasive surgery for uterine fibroids admitted to our hospital from February 2020 to February 2023 were selected as the study group,and another 80 patients with urinary tract infection after minimally invasive surgery for uterine fibroids treated in our hospital during the same period were selected as the control group.ELISA method was applied to detect the expression levels of serum HBD-3 and LRG1.Multivariate logistic regression was applied to analyze the relevant factors affecting the occurrence of urinary tract infections after minimally invasive surgery for uterine fibroids.ROC curve was applied to analyze the diagnostic value of serum HBD-3 and LRG1 levels for urinary tract infections after minimally invasive surgery for uterine fibroids.Results The proportion of diabetes history,operation time,and hospital stay in the study group were obviously higher than those in the control group(P＜0.05).The serum HBD-3 level in the study group was obviously lower than that in the control group,and the serum LRG1 level was greatly higher than that in the control group(P＜0.05).Serum HBD-3,LRG1,history of diabetes,operation time,and hospital stay were related factors affecting the incidence of urinary tract infection after minimally invasive surgery for uterine fibroids(P＜0.05).The area under the curve(AUC)of serum HBD-3,LRG1,and their combination in diagnosing urinary tract infections after minimally invasive surgery for uterine fibroids was 0.810,0.774,and 0.894,respectively,which were superior to their respective single diagnoses(Zcombination-HBD-3=2.670,Z combination-LRG1=3.799,P=0.008,0.000),the sensitivity and specificity of combined diagnosis were 88.75％and 75.00％,respectively.Conclusion Serum HBD-3 level obviously decreases and serum LRG1 level greatly increases in patients with urinary tract infections after minimally invasive surgery for uterine fibroids.The combined detection of the two has a more efficient diagnostic value for the occurrence of urinary tract infections after minimally invasive surgery for uterine fibroids.
minimally invasive surgery for uterine fibroidsβ-defensin-3leucine rich alpha-2-glycoprotein 1urinary tract infectiondiagnostic value
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