Analysis of the distribution characteristics of pathogenic bacteria and changes in inflammatory factor levels in elderly patients with Parkinson's disease complicated with pulmonary infection
Objective To analyze the distribution characteristics of pathogenic bacteria and the level of inflammatory factors in elderly patients with Parkinson's disease complicated with pulmonary infection.Methods A retrospective analysis was conducted on the clinical data of 107 elderly patients with Parkinson's disease complicated with pulmonary infection.The results of pathogen culture and the levels of serum inflammatory factors were collected,and the types of pathogenic bacteria and the changes in the levels of inflammatory factors were analyzed.Results Among the 107 elderly patients with Parkinson's disease complicated with pulmonary infection,a total of 107 strains of pathogenic bacteria were isolated.Among them,Gram-negative bacteria accounted for 53.27％,including Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Acinetobacter baumannii,and Stenotrophomonas maltophilia.Gram-positive bacteria accounted for 37.38％,mainly including Staphylococcus aureus,Streptococcus pneumoniae,and Staphylococcus epidermidis.Fungi accounted for 9.35％,mainly Candida albicans and Candida tropicalis.85 patients had dysphagia,and 22 patients had no such symptom.In the dysphagia group,the proportion of Gram-negative bacteria was 56.47％,Gram-positive bacteria was 35.29％,and fungi was 8.24％.In the non-dysphagia group,Gram-negative bacteria was 40.91％,Gram-positive bacteria was 45.45％,and fungi was 13.64％.There was no statistically significant difference in the constituent ratio of pathogenic bacteria between the two groups(P＞0.05).Among the 57 strains of Gram-negative bacteria,they showed relatively high resistance rates to the third-generation quinolones levofloxacin and ciprofloxacin,with resistance rates of 59.65％and 56.14％respectively.The resistance rates to carbapenems imipenem and meropenem and aminoglycoside amikacin were relatively low,being 12.28％,17.54％,and 15.79％respectively.Among the 40 strains of Gram-positive bacteria,they showed relatively high resistance rates to penicillin G,erythromycin,clindamycin,gentamicin,and levofloxacin,which were 82.5％,77.5％,72.5％,60％,and 55％respectively.No resistant strains to vancomycin and teicoplanin were produced.In the group of patients with pulmonary infection and dysphagia,the serum IL-1β was(10.81±1.91)μg/mL,TGF-β was(111.02±14.09)μg/mL,IL-17 was(102.64±20.89)μg/mL,and IL-23 was(66.01±11.24)μg/mL.In the group of patients with pulmonary infection without dysphagia,the serum IL-1β was(7.45±1.42)μg/mL,TGF-β was(93.43±13.66)μg/mL,IL-17 was(84.81±19.69)μg/mL,and IL-23 was(55.71±14.35)μg/mL.The differences in serum levels of IL-1β,TGF-β,IL-17,and IL-23 between the two groups were statistically significant(P＜0.05).Conclusion In elderly patients with Parkinson's disease complicated with pulmonary infection,pathogenic bacteria were widely distributed,mainly Gram-negative bacteria,and showed high resistance to some commonly used antibiotics.There was no significant difference in the composition of pathogenic bacteria between patients with dysphagia and those without dysphagia.However,the serum levels of inflammatory factors in the former were significantly increased,suggesting that dysphagia might aggravate the inflammatory response and needed attention in clinical treatment.Therefore,reasonable selection of antibiotics and regulation of inflammatory factors were of great significance for improving the therapeutic effect.
NETL
NSTL
万方数据
