Study on the changes in gut microbiota of patients with acute myocardial infarction and its correlation with heart failure
Objective To analyze the changes of intestinal flora in patients with acute myocardial infarction and its correlation with heart failure.Methods 92 patients with acute myocardial infarction admitted to Tongling municipal hospital from April 2021 to June 2024 were selected as the study group,and 30 healthy volunteers were selected as the control group.The intestinal flora of the two groups was detected by intestinal flora culture method.The patients were followed up for 30 days.According to the occurrence of heart failure in patients with acute myocardial infarction,they were divided into occurrence group and non occurrence group.The intestinal flora,N-terminal pro-B-type natriuretic peptide(NT proBNP)and left ventricular ejection fraction(LVEF)levels of the two groups were compared.Pearson correlation test was used to analyze the relationship between intestinal flora and NT proBNP,LVEF analyze the influencing factors of heart failure in patients with acute myocardial infarction.Results the number of Bacteroides,Bifidobacterium,Lactobacillus and total anaerobic bacteria in the study group were less than those in the control group,while the number of enterobacter,Enterococcus,Clostridium,fungi and total aerobic bacteria in the study group were more than those in the control group(P＜0.05).The number of Bacteroides,Bi fidobacteria,lactic acid bacteria and total anaerobic bacteria in the heart failure group was less than that in the non heart failure group,while the number of Enterobacter,Enterococcus and total aerobic bacteria in the heart failure group was more than that in the non heart failure group(P＜0.05).The NT proBNP level in the occurrence group was higher than that in the non occurrence group,and the LVEF was lower than that in the non occurrence group(P＜0.05).Pearson correlation analysis showed that the number of Bacteroides,Bifidobacteria,Lactobacillus and total anaerobic bacteria in patients with acute myocardial infarction was negatively correlated with NT proBNP level,and positively correlated with LVEF(P＜0.05);The number of Enterobacter,Enterococcus and total aerobic bacteria was positively correlated with NT proBNP level,and negatively correlated with LVEF(P＜0.05).Logistic regression analysis showed that Bacteroides,Bifidobacterium,Lactobacillus,total anaerobic bacteria and LVEF were the protective factors of heart failure in patients with acute myocardial infarction,while Enterobacter,Enterococcus,total aerobic bacteria and NT proBNP were the risk factors of heart failure in patients with acute myocardial infarction(P＜0.05).Conclusion there are changes in intestinal flora in patients with acute myocardial infarction,which is related to the occurrence of heart failure.
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