Correlation analysis between KDM2A and KDM5A protein levels with high-risk HPV infection in cervical cancer patients
Objective To investigate the protein levels of histone lysine demethylase 2A(KDM2A)and histone lysine demethylase 5A(KDM5A)in cervical cancer patients,and to analyze their correlation with high-risk human papillomavirus(HR-HPV)infection.Methods A total of 78 cervical cancer patients admitted from January 2021 to January 2024 were selected as the cervical cancer group.During the same period,72 patients with cervical intraepithelial neoplasia(CIN)were selected as the CIN group,and 76 healthy individuals were selected as the control group.The general information of the examinee was collected.Enzyme linked immunosorbent assay(ELISA)was applied to detect serum levels of KDM2A and KDM5A in three groups.The serum levels of KDM2A and KDM5A were compared among different grades of the CIN group.The HR-HPV infection status of patients with different grades and stages of cervical cancer in the CIN group was compared.The relationship between serum levels of KDM2A and KDM5A and clinical pathological characteristics of cervical cancer patients was analyzed.Results The serum levels of KDM2A and KDM5A in the cervical cancer group were higher than those in the CIN group and control group(P＜0.05).There were differences in serum KDM2A and KDM5A levels among different grades in the CIN group(P＜0.05).The total infection rates of HR-HPV in FIGO stage Ⅰ-Ⅱ and FIGO stage Ⅲ cervical cancer patients were higher than those in CIN stage Ⅰ and CIN stage Ⅱ,the total infection rate of HR-HPV in FIG()stage Ⅲ cervical cancer patients was higher than that in CIN stage Ⅲ(P＜0.05).The serum levels of KDM2A and KDM5A were correlated with HPV viral load,tumor differentiation degree,and FIG()staging in cervical cancer patients(P＜0.05).Conclusion The serum levels of KDM2A and KDM5A are elevated in cervical cancer patients,which are associated with HR-HPV infection.
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