Correlation analysis between pathogen types and serum index levels in patients with peritoneal dialysis-related peritonitis
Objective To analyze the distribution characteristics of pathogen types in patients with peritoneal dialysis-associated peritonitis(PDAP)and its correlation with serum indexes,in order to provide a theoretical basis for clinical diagnosis and treatment.Methods A retrospective analysis was conducted on the clinical data of 103 patients with PDAP who were admitted to our hospital from April 2020 to December 2023.Peritoneal dialysis fluid specimens from the patients were collected for pathogen identification and drug sensitivity testing.Venous blood was drawn from the patients to determine the levels of serum procalcitonin(PCT),red blood cell distribution width(RDW),and neutrophil/lymphocyte ratio(NLR),and the correlation between these indicators and pathogen types was analyzed.Results A total of 69 strains of pathogenic bacteria were detected,including 51 strains of Gram-positive bacteria(accounting for 73.91％),including Staphylococcus epidermidis,Staphylococcus aureus,etc.;18 strains of Gram-negative bacteria(accounting for 26.09％),including Escherichia coli,Klebsiella pneumoniae,etc.There was a statistically significant difference in the levels of serum PCT,RDW,and NLR between patients with Gram-positive bacterial infection and patients with Gram-negative bacterial infection(P＜0.05).By the receiver operating characteristic(ROC)curve the value of various serum indicators was evaluated in diagnosing the types of infectious pathogens in patients with PDAP,it was found that the single diagnosis of serum PCT,RDW,and NLR and the combined diagnosis of the three had different cut-off values,areas under the curve,sensitivities and specificities.Among them,the combined diagnosis of the three had the highest area under the curve of 0.913,a sensitivity of 88.9％,and a specificity of 90.2％.Conclusion The main pathogens in patients with PDAP were Gram-positive bacteria.Serum PCT,RDW,and NLR indicators were significantly correlated with pathogen types and had important guiding significance for clinical diagnosis and treatment.In particular,the combined application of these three indicators can significantly improve the accuracy of diagnosis,help take targeted treatment measures in time,reduce the treatment risk of patients,and improve prognosis.
Peritoneal dialysis-associated peritonitispathogen typeprocalcitoninred blood cell distribution widthneutrophil/lymphocyte ratio
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