The levels and clinical significance of serum MIP-1 α and HBD3 in elderly patients with pulmonary infection during the rehabilitation period after stroke
Objective To investigate the clinical significance of serum macrophage inflammatory protein-1α(MIP-1α)and human beta defensin 3(HBD3)in elderly patients with pulmonary infection during the rehabilitation period after stroke.Methods A total of 194 elderly stroke patients admitted to our hospital during the rehabilitation period from January 2022 to January 2024 were collected.They were grouped into an infection group(66 cases)and a non infection group(128 cases)based on the occurrence of pulmonary infection during the rehabilitation period.The National Institutes of Health Stroke Scale(NIHSS)was used to assess the degree of stroke in patients after admission.Clinical data were collected from patients during rehabilitation period.ELISA method was applied to detect serum MIP-1 α and HBD3.Spearman was applied to analyze the correlation between serum MIP-1 α,HBD3,NIHSS,and CPIS.Logistic regression was applied to analyze the influencing factors of pulmonary infection in elderly patients during the rehabilitation period after stroke.ROC was applied to analyze the predictive value of serum MIP-1 α and HBD3 for pulmonary infection in elderly patients during the rehabilitation period after stroke.Results The proportions of patients with dysphagia,tracheotomy,invasive procedures,diabetes history,smoking history and hospitalization time＞14 days in the infection group were higher than those in the non infection group,the WBC,CRP,NIHSS,CPIS,MIP-1 α,HBD3 were higher than those in the non infection group,while ALB and PLT were lower than those in the non infection group(P＜0.05).Dysphagia[OR=3.341(1.175-9.497)],tracheostomy[OR=2.665(1.152-6.166)],invasive procedures[OR=1.890(1.362-2.622)],long hospital stay[OR=3.872(1.392-10.771)],high levels of CRP[OR=4.073(2.709-6.123)],MIP-1 α[OR=1.455(1.037-2.042)],and HBD3[OR=2.508(1.324-4.751)]were risk factors for pulmonary infection in elderly patients during the rehabilitation period after stroke(P＜0.05).Serum MIP-1 α and HBD3 were positively correlated with NIHSS(r=0.452,0.407)and CPIS(r=0.531,0.395)(P＜0.05).The AUC of serum MIP-1 αcombined HBD3(0.925)for predicting pulmonary infection in elderly patients during the rehabilitation period after stroke was higher than that of serum MIP-1 α and HBD3 alone(0.796,0.780)(P＜0.05).Conclusion The serum levels of MIP-1 α and HBD3 are higher in elderly patients with pulmonary infection during the rehabilitation period after stroke.MIP-1 α and HBD3 are influencing factors for pulmonary infection in elderly patients during the rehabilitation period after stroke.Combined detection of MIP-1 α and HBD3 may predict pulmonary infection in patients.
NETL
NSTL
万方数据
