Analysis of genital Chlamydia trachomatis infection and adverse pregnancy outcomes during pregnancy
Objective The genital Chlamydia trachomatis infection and adverse pregnancy outcomes during pregnancy were analyzed.Methods A total of 1 375 pregnant women admitted to our hospital were selected as the research objects.The clinical data of the patients were collected,and genital Chlamydia trachomatis detection and genotype analysis and genital tract flora detection were carried out.The impact of C.trachomatis infection on the genital tract flora and pregnancy outcomes of pregnant women was compared and analyzed.Results A total of 78 pregnant women were detected with C.trachomatis infection,with an infection rate of 5.67％.Among them,42 cases were single-genotype infections(53.85％),including genotypes D,E,F,G,H,J,and K,mainly genotype E;27 cases were double-genotype infections(34.62％),including E+F,D+K,J+K,E+K,D+J types,mainly E+F type;9 cases were multiple-genotype infections(11.54％),including E+J+K,E+F+K,F+H+J,D+H+K types,mainly E+J+K type.C.trachomatis infection had a certain impact on the genital tract flora of pregnant women.There were statistically significant differences in the density,diversity of vaginal flora and manifestations of vaginitis between the infected group and the uninfected group,but there was no significant difference in the comparison of dominant bacteria.The incidence of adverse pregnancy outcomes such as premature rupture of membranes,premature delivery,and postpartum hemorrhage in the infected group was higher than that in the uninfected group,and the difference was statistically significant.There was no significant difference in the incidence of fetal distress.In the multiple-genotype C.trachomatis infection group,the incidence of adverse pregnancy outcomes such as premature rupture of membranes,premature delivery,neonatal pneumonia,and neonatal asphyxia was significantly higher than that in the single-genotype and double-genotype infection groups.Conclusion The infection rate of C.trachomatis in the genital tract of pregnant women was relatively high,and it was related to adverse pregnancy outcomes and changes in the genital tract flora.Different genotype infections had different effects on pregnancy outcomes.In particular,multiple-genotype infections should attract more clinical attention.For such infections,more effective prevention and treatment measures need to be taken to reduce the risk of adverse pregnancy outcomes and ensure the health of mothers and infants.
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