Research progress on Plasmodium membrane protein complexes
Malaria is one of the world's three most serious infectious diseases which caused by Plasmodium spp.The Plasmodium merozoite,ookinete,and sporozoite all have characteristic endomembrane complexes(IMCs).IMC is localized under the plasma membrane and is closely linked to the subpellicular protein network on the cytoplasmic side of the membrane.IMC is involved in the parasite development and invasion of the host cells by providing a sup-port backbone during cell division,maintaining cell morphology and stability.In-depth studies of the structure,func-tion and transcriptional regulation mechanism of IMC protein are of great significance for the development of corre-sponding inhibitors or blockers to block malaria transmission.In this paper,we reviewed the research progress of IMC protein structure and transcriptional regulation mechanisms in recent years.
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