疟原虫内膜复合体蛋白研究进展
Research progress on Plasmodium membrane protein complexes
韩竹茜 1朱晓彤1
作者信息
- 1. 中国医科大学基础医学院免疫教研室,辽宁沈阳 110122
- 折叠
摘要
疟疾是由疟原虫感染所致的全球危害最严重的三大传染病之一.疟原虫的裂殖子、动合子和子孢子均具有特征性的内膜复合体(IMC).IMC定位于质膜下,在胞质侧与膜下网络紧密相连.IMC在细胞分裂过程中提供支撑骨架,维持细胞的形态和稳定性,参与疟原虫发育和入侵宿主细胞等过程.深入研究IMC蛋白的结构、功能和转录调控机制,对研发相应的抑制剂或阻断剂以阻断疟疾传播有重要意义.本文就近年来IMC蛋白结构及其转录调控机制的研究进展进行综述.
Abstract
Malaria is one of the world's three most serious infectious diseases which caused by Plasmodium spp.The Plasmodium merozoite,ookinete,and sporozoite all have characteristic endomembrane complexes(IMCs).IMC is localized under the plasma membrane and is closely linked to the subpellicular protein network on the cytoplasmic side of the membrane.IMC is involved in the parasite development and invasion of the host cells by providing a sup-port backbone during cell division,maintaining cell morphology and stability.In-depth studies of the structure,func-tion and transcriptional regulation mechanism of IMC protein are of great significance for the development of corre-sponding inhibitors or blockers to block malaria transmission.In this paper,we reviewed the research progress of IMC protein structure and transcriptional regulation mechanisms in recent years.
关键词
疟原虫/内膜复合体/肺泡蛋白/棕榈酰化/磷酸化Key words
Plasmodium/Inner membrane complex/Alveolins/Palmitoylation/Phosphorylation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据