Research advances on transmission-blocking vaccines targeting Plasmodium sexual stage
Malaria remains a major global health challenge.At present,due to the application of drugs and related technologies,the burden of disease has been reduced to a certain extent,but morbidity and mortality remain very high.With the widespread emergence of drug resistance,it is urgent to explore and develop new anti-malarial strategies to effectively control and block the spread of malaria.The transmission-blocking vaccine(TBV),which tar-gets the sexual stage,is a good option to control the transmission of Plasmodium from human hosts to mosquito vec-tors.The development of TBV has attracted attention domestically and internationally.It is considered to be one of the new technologies for malaria control.This article summarizes the research and development of TBV,as well as the discovery and progress of candidate antigens,and provides a theoretical reference for further research on TBV.
NETL
NSTL
万方数据
