寄生虫及其相关物治疗炎症性肠病转归进展
Advances in the treatment of inflammatory bowel disease with parasites and their agents
徐凯 1陈力 1林登峰1
作者信息
- 1. 浙江大学医学院附属邵逸夫医院肛肠外科,杭州 310016
- 折叠
摘要
炎症性肠病(IBD)是一种病因尚未完全明确、以肠道症状为主的肠道疾病.该病迁延难愈,为国内外肠道疾病的疑难病,严重影响患者生存质量.近年研究发现,寄生虫及其相关物作用宿主后,可诱导一系列免疫应答,调节免疫微环境及改善肠道菌群,减轻炎症症状.本文就寄生虫及其相关物实验治疗IBD的最新研究进展进行综述,以期为治疗IBD的新型药物研发提供参考.
Abstract
Inflammatory bowel disease(IBD)is a type of intestinal disease whose etiology has not been com-pletely defined and is mainly characterized by intestinal symptoms.This disease is protracted and difficult to cure,making it a challenging medical condition both domestically and internationally,and seriously affects the life quality of the patients.Recently,it has been found that parasites and their related agents can regulate the immune microenvi-ronment,improve intestinal flora and reduce inflammatory symptoms by inducing a series of immune responses after acting on the host.In this paper,the latest research advances in the experimental treatment of IBD with parasites and related agents are reviewed to provide a reference for developing new drugs for the treatment of IBD.
关键词
寄生虫/炎症性肠病/实验治疗Key words
Parasite/Inflammatory bowel disease/Experimental treatment引用本文复制引用
基金项目
浙江省教育厅一般科研项目(Y202249521)
出版年
2024
NETL
NSTL
万方数据