[Objective]To investigate clinical efficacy of high tibial osteotomy(HTO)combined with arthroscopic debridement(AD)and platelet-rich plasma(PRP)intraarticular injection for medial knee osteoarthritis(mKOA).[Methods]A retrospective study was conduct-ed on 33 patients who received HTO for mKOA in our hospital from November 2015 to July 2019.According to doctor-patient communica-tion,17 patients received HTO+AD+PRP treatment(combination group),and the other 16 patients received HTO treatment only.The periop-erative,follow-up and imaging data of the two groups were compared.[Results]All patients in both groups were operated on smoothly,with-out significant differences in operation time,total incision length,intraoperative blood loss,incision healing grade,ambulation time and hos-pital stay between the two groups(P＞0.05).All patients were followed up for more than 30 months,and the combined group resumed full weight-bearing activities significantly earlier than the HTO group[(58.1±4.6)days vs(66.1±4.0)days,P＜0.05].The VAS and WOMAC scores decreased significantly(P＜0.05),while Lysholm and HSS scores significantly increased over time in both groups(P＜0.05).Although there was no significant differences in abovesaid scores between the two groups before operation(P＞0.05),the combined group proved signifi-cantly superior to the HTO group in terms of VAS[(2.4±0.5)vs(2.8±0.5),P＜0.05],WOMAC[(18.4±2.0)vs(23.7±2.5),P＜0.05],HSS[(80.8± 3.0)vs(73.3±2.5),P＜0.05]and Lysholm score[(79.1±3.6)vs(71.4±2.8),P＜0.05]at the latest follow-up.Regarding imaging,the medial prox-imal tibial angle(MPTA)and femorotibial angle(FTA)significantly improved(P＜0.05),whereas the K-L classification remained unchanged in both groups at 6 months and 1 year after surgery compared with those preoperatively(P＞0.05).However,there were no statistically signifi-cant differences in the above imaging items between the two groups at any time points accordingly(P＞0.05).[Conclusion]HTO combined with arthroscopic debridement and PRP does significantly improve knee joint function,relieve pain and improve patient satisfaction,and achieves clinical efficacy better than that of HTO only.
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