Periprosthetic joint infection(PJI)is a catastrophic complication after arthroplasty.Once it happens,it will bring great psy-chological and economic burden to patients,so timely and correct diagnosis is crucial.At present,the commonly used diagnostic methods are formulated according to clinical manifestations,imaging manifestations,serum and synovial biomarkers,etc.With the discovery and experi-ment of more serum and synovial biomarkers,the examination of biochemical indicators become increasingly important,regardless of some synovial biomarkers easily affected by inflammation.In recent years,leukocyte esterase has been paid more and more attention,which has high sensitivity and specificity for diagnosis of PJI,despite of that other clinical evaluations and auxiliary examinations should be combined in the diagnosis.Effectiveness of leukocyte esterase for diagnosis of PJI need further research.This article comprehensively analyzes the cur-rent clinical research on synovial leucocyte esterase,and reviews its research status and clinical value in the diagnosis of PJI.
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