[Objective]To investigate the efficacy of local injection of dexamethasone combined with ropivacaine(DR)in the preven-tion of incision-related complications of open reduction and internal fixation(ORIF)of calcaneal fractures.[Methods]A retrospective study was conducted on 136 patients(137 feet)who underwent ORIF for calcaneal fractures in our hospital from January 2019 to October 2022.According to doctor-patient communication,68 patients(68 feet)received intraoperative DR injection around the incision(the DR group),while the other 68 patients(69 feet)had no DR injected(the routine group).The perioperative data of the two groups were compared.[Results]Although there were no significant differences in operation time,incision length and intraoperative blood loss between the two groups(P>0.05),the DR group proved significantly superior to the routine group in terms of incision swelling time[(4.7±1.1)days vs(6.8± 2.9)days,P<0.001],exudation time[(3.6±1.6)days vs(6.4±1.2)days,P<0.001],postoperative hospitalization time[(7.3±1.2)days vs(8.5± 2.1)days,P<0.001]and postoperative pain VAS score[1 day postoperatively,(5.2±1.2)vs(8.4±1.1),P<0.001;2 days postoperatively,(4.8± 1.3)vs(6.6±1.8),P<0.001;3 days postoperatively,(3.4±1.8)vs(4.3±1.6),P<0.001].In addition,the former was significantly better than the latter in incision healing grade[A/B/C,(66/0/2)vs(58/2/9),P=0.010],howerve,there was no statistically significant difference in postopera-tive stitches removal time between the two groups(P>0.05).[Conclusion]Local injection of dexamethasone combined with ropivacaine around the incision does effectively reduce postoperative pain and incision-related complications in ORIF of calcaneal fracture.