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老年股骨转子间骨折患者术后输血的相关因素

Factors related to postoperative blood transfusion of femoral intertrochanter fractures in elderly

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[目的]分析老年转子间骨折术后输血的危险因素,建立预测模型并对其验证.[方法]回顾性分析本院2016年12月-2021年12月收治的老年转子间按骨折共358例患者临床资料.按术后是否输血,分为输血组和非输血组,采用单因素和多因素分析得出术后输血的危险因素.建立预测模型,对模型效能进行评定.[结果]358例患者中,共168例术后输血,占46.9%.单项因素比较显示,输血组患者较非输血组年龄更大[(80.7±8.5)岁vv(76.6±8.7)岁,P<0.001]、BMI更小[(20.7±3.3)kg/m2 vs(21.5±3.7)kg/m2,P=0.015]、高血压占比更高[(105/63)vs(93/97),P=0.010]、骨折类型更严重[A1/A2/A3,(40/93/35)vs(80/83/27),P<0.001]、手术时间更长[(122.9±56.6)min vs(101.4±30.5)min,P<0.001]、术中出血量更多[(258.3±218.9)ml vs(130.5±94.9)ml,P<0.001]、术前 HB 更低[(93.1±14.8)g/L vs(111.6±14.2)g/L,P<0.001]、术前 Alb 更低[(34.7±8.2)g/L vs(36.8±4.5)g/L,P=0.002],差异均有统计学意义.逻辑回归分析显示:年龄(OR=1.053,P=0.007)、手术时间(OR=1.008,P=0.025)、术中出血量(OR=1.007,P<0.001)是术后输血发生的独立危险因素;而BMI(OR=0.900,P=0.025)和术前血红蛋白(OR=0.904,P<0.001)是术后输血的独立保护因素.基于逻辑回归结果所得的术后输血预测方程曲线下面积AUC为0.894,95%CI0.862~0.927,最佳临界值为0.578,敏感度为74.4%,特异度为88.4%.[结论]高龄、手术时间长、术中出血多、低BMI和低血红蛋白是术后发生输血的独立危险因素.术后输血预测模型有助于临床判断输血发生风险并提前预防.
[Objective]To analyze the risk factors of postoperative blood transfusion of femoral intertrochanteric fracture in the elderly,and an established prediction equation was verified.[Methods]A retrospective study was done on 358 elderly patients who received surgi-cal treatment for femoral intertrochanteric fractures in our hospital from December 2016 to December 2021.The patients were divided into transfusion group and non-transfusion group according to whether postoperative blood transfusion occurred.The univariate comparisons and multi-factor binary logistic regression analysis were conducted to search the relative factors,and then a prediction model was estab-lished with its efficiency evaluated.[Results]Among the 358 patients,168(46.9%)received postoperative blood transfusion.In term of uni-variate comparison,the transfusion group were significantly older in age[(80.7±8.5)years vs(76.6±8.7)years,P<0.001],lower BMI[(20.7± 3.3)kg/m2 vs(21.5±3.7)kg/m2,P=0.015],higher prevalence of hypertension[(105/63)vs(93/97),P=0.010],and more severe fracture types[A1/A2/A3,(40/93/35)vs(80/83/27),P<0.001],longer operation time[(122.9±56.6)min vs(101.4±30.5)min,P<0.001],more intraopera-tive blood loss[(258.3±218.9)ml vs(130.5±94.9)ml,P<0.001],lower preoperative Hb[(93.1±14.8)g/L vs(111.6±14.2)g/L,P<0.001],and lower preoperative Alb[(34.7±8.2)g/L vs(36.8±4.5)g/L,P=0.002]than the non-transfusion group,and all abovesaid were statistically sig-nificant between the two groups.As results of logistic regression analysis,the age(OR=1.053,P=0.007),operation time(OR=1.008,P=0.025),intraoperative blood loss(OR=1.007,P<0.001)were the independent risk factors for postoperative transfusion,while the BMI(OR=0.900,P=0.025)and preoperative hemoglobin(OR=0.904,P<0.001)were the independent protective factor.Based on the logistic regres-sion results,a prediction equation was established,which proved area under curve(AUC)of 0.894,95%CI 0.862~0.927,with cutoff of 0.578,the sensitivity of 74.4%,and the specificity of 88.4%by the ROC analysis.[Conclusion]The advanced age,longer operation time,more intraoperative bleeding,lower BMI and lower hemoglobin are independent risk factors for postoperative blood transfusion.The predic-tion model of postoperative blood transfusion might be helpful to judge the risk of transfusion and prevent it in advance.

elderlyfemoral intertrochanteric fracturepostoperative blood transfusionrelated factorsprediction

王卓、刘序强、陈延朕、钟元武、李晓峰、戴闽、聂涛

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南昌大学第一附属医院骨科医院,江西南昌 330000

老年人 股骨转子间骨折 术后输血 相关因素 预测

省卫健委科技计划项目省中医药科技计划项目

2021302352021Z020

2024

中国矫形外科杂志
中国残疾人康复协会 中国人民解放军第八十八医院

中国矫形外科杂志

CSTPCD北大核心
影响因子:1.521
ISSN:1005-8478
年,卷(期):2024.32(2)
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