[Objective]To compare the clinical efficacy of vesselplasty(VP)with or without manual reduction for osteoporotic verte-bral compression fracture(OVCF).[Methods]A retrospective study was done on 65 patients who underwent VP for OVCF in our hospital from July 2020 to April 2022.According to doctor-patient communication,31 patients had manual reduction conducted,followed by the VP(the reduction group),while the other 34 patients underwent VP without manual reduction before surgery(the non-reduction group).The documents regarding to perioperative period,follow-up and images were compared between the two groups.[Results]All patients were successfully operated on without serious complications.The reduction group proved significantly superior to the non-reduction group in terms of operation time[(31.4±6.7)min vs(38.9±13.0)min,P=0.006]and the bone cement leakage rate(22.6％vs 58.8％,P=0.003),al-though there were no significant differences in intraoperative fluoroscopy times,bone cement injection amount,postoperative ambulation time,hospital stay and hospitalization cost between the two groups(P＞0.05).All patients were followed up for more than 1 year,and there was no significant difference in the time to resume full weight-bearing activities between the two groups(P＞0.05).The VAS and ODI scores decreased significantly over time in both groups(P＜0.05),whereas which were not statistically significant between the two groups at any timepoints accordingly(P＞0.05).With regard of imaging,the local kyphotic Cobb angle and anterior vertebral height were significantly im-proved in both groups at the latest follow-up compared with those preoperatively(P＜0.05),however,there were no statistically significant differences in the local kyphotic Cobb angle and anterior vertebral height between the two groups at anycorresponding time points(P＞0.05).[Conclusion]The VP combined with manual reduction does better reduce the chance of bone cement leakage,and shorten the opera-tive time in the treatment of osteoporotic vertebral compression fractures.
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