[Objective]To evaluate the clinical efficacy of percutaneous endoscopic interlaminar discectomy(PEID)combined with in-tervertebral implantation of platelet-rich plasma capsule for lumbar disc herniation(LDH).[Methods]A retrospective study was performed on 87 patients who received PEID for LDH from March 2018 to February 2020.According to the preoperative doctor-patient communica-tion,45 patients received PEID combined with PRP capsule(the PRP group),while other 42 patients received PEID alone(the non-PRP group).By propensity score matching(PSM),30 patients in the PRP group and 30 patients in the non-PRP were included in this study.The perioperative period,follow-up and imaging data of the two groups were compared.[Results]There were no significant differences in opera-tion time,total incision length,intraoperative blood loss,intraoperative fluoroscopy times,walking time,incision healing grade and hospital stay between the two groups(P＞0.05).The follow-up period lasted for(27.2±2.0)months on a mean,and there was no significant difference in time to resume full weight-bearing activity between the two groups(P＞0.05).The VASs,ODI and JOA score were significantly improved over time in both groups(P＜0.05).At 6 months postoperatively,the PRP group proved significantly superior to the non-PRP group in terms of low back pain VAS[(1.9±0.8)vs(2.5±0.8),P＜0.05],leg pain VAS[(2.6±0.9)vs(3.1±0.9),P＜0.05],ODI[(24.5±8.0)vs(29.5±8.3),P＜0.05]and JOA score[(22.2±2.2)vs(21.0±2.1),P＜0.05].Radiographically,the dural sac cross-sectional surface area(DCSA),disc height in-dex(DHI),and signal intensity ratio(SIR)between nucleus pulposus and cerebrospinal fluid were significantly improved in both group over time(P＜0.05).At the last follow-up,the PRP group were significantly better than non-PRPgroup in terms of DCSA[(215.6±12.9)mm2 vs(208.3±13.2)mm2,P=0.034],Pfirrmann grade of disc degeneration[Ⅰ/Ⅱ/Ⅲ/Ⅳ/Ⅴ,(0/0/23/7/0)vs(0/0/15/11/4),P=0.037],and SIR[(24.6± 2.3)％vs(23.0±3.3)％,P=0.033].[Conclusion]The PEID combined with PRP capsule is effective and safe in the treatment of LDH,and might delay the degeneration of intervertebral disc to a certain extent.
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