[Objective]To investigate the correlation between imaging and clinical data in endoscopic decompression for lumbar spinal stenosis(LSS).[Methods]From January 2020 to August 2022,76 patients with LSS underwent percutaneous transforaminal endoscopic de-compression in our hospital.At the last follow-up,patients were grouped according to the clinical efficacy evaluated by modified Macnab cri-teria.The clinical and imaging data of patients were compared,and the correlation between the imaging parameters and VAS score or ODI score was analyzed.[Results]According to Macnab criteria,36 cases were excellent,32 cases were good,and 8 cases were fair at the last fol-low-up.There were significantly differences in terms of VAS score[(1.3±0.2)vs(1.7±0.4)vs(2.6±0.8),P<0.001],ODI score[(20.9±4.3)%vs(25.5±5.3)%vs(32.4±3.4)%,P<0.001],as well as the radiographic measurements including central canal cross-sectional area(CCCSA)[(169.3±18.3)mm2 vs(164.5±15.8)mm2 vs(156.4±13.4)mm2,P<0.001],lateral recess anteroposterior diameter(LRAPD)[(5.3±0.7)mm vs(4.9±0.6)mm vs(4.2±0.4)mm,P<0.001],sagittal area of the intervertebral foramen(SAIF)[(90.2±9.0)mm2 vs(86.4±8.1)mm2 vs(80.5±6.8)mm2,P<0.001],dural sac cross-sectional area(DSCSA)[(138.5±10.3)mm2 vs(134.4±9.2)mm2 vs(126.3±8.6)mm2,P<0.001]and the dural sac maximum sagittal diameter(DSMSD)[(21.7±4.0)mm vs(19.6±3.3)mm vs(17.9±2.8)mm,P<0.001].As results of correlation analysis,the VAS score was significantly negatively correlated with CCCSA(r=-0.429,P<0.001),LRAPD(r=-0.346,P<0.001),SAIF(r=-0.354,P<0.001),DSCSA(r=-0.216,P=0.023)and DSMSD(r=-0.254,P=0.014).Similarly,the ODI score proved significantly negatively correlated with CCCSA(r=-0.420,P<0.001),LRAPD(r=-0.335,P<0.001),SAIF(r=-0.373,P<0.001),DSCSA(r=-0.213,P=0.022)and DSMSD(r=-0.252,P=0.013).[Conclusion]After percutaneous transforaminal endoscopic decompression for LSS,the measured parameters of CT and MRI images are significantly correlated with clinical pain and dysfunction scores.