[Objective]To compare the expression of transforming growth factor-β1(TGF-β1)in serum and in knee cartilage and sub-chondral bone in knee osteoarthritis(KOA)and non-KOA patients.[Methods]Thirty patients with KOA who underwent total knee replace-ment(the KOA group)and another 30 patients without KOA,including 13 patients with acute anterior cruciate ligament injury who under-went ligament reconstruction and intercondylar fossaplasty(the control group)had TGF-β1 detected in serum,knee cartilage and subchon-dral bone.[Results]The results of TGF-β1 in serum by ELISA were(1 929.1±76.8)pg/ml in the KOA group,while(1 611.4±105.9)pg/ml in the control group,with a statistically significant difference(P=0.022).Immunohistochemical staining of TGF-β1 in cartilage and bone tis-sues showed that there were 24 strong positive cases and 6 negative cases in KOA group with a positive rate of 80.0％,whereas 4 positive cas-es and 9 negative cases with the positive rate of 30.8％in the control group,and the positive rate of TGF-β1 immunohistochemical staining in KOA group was higher than that in control group(P=0.002).[Conclusion]Compared with non-KOA patients,TGF-β1 expression in se-rum and knee joint related tissues was significantly increased in the KOA patients.
knee osteoarthritistransforming growth factor-β1(TGF-β1)cartilagesubchondral bone
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