[Objective]To evaluate the safety and efficacy of endoscopic discectomy with targeted foraminoplasty by visual trephine in the treatment of lumbar disc prolapse.[Methods]A retrospective study was done on 58 patients who underwent percutaneous transforaminal endoscopic discectomy(PTED)for lumbar disc prolapse in our department from March 2019 to July 2021.According to doctor-patient com-munication,30 patients underwent targeted foraminoplasty with visual trephine in the PTED(the visible group),with other 28 patients were with invisible trephine(the invisible group).The perioperative,follow-up and imaging data of the two groups were compared.[Results]The visual group proved significantly superior to the invisible group in terms of operation time[(63.2±5.3 min)vs(75.8±7.4)min,P＜0.001],intra-operative blood loss[(51.8±3.4)ml vs(59.2±4.9)ml,P＜0.001]and intraoperative fluoroscopy times[(4.2±0.6)times vs(10.5±1.2)times,P＜0.001],but there was no significant difference in incision length and hospital stay between the two groups(P＞0.05).The mean follow-up time was of(17.4±6.5)months,and there was no significant difference between the two groups in the time to return to full weight-bearing ac-tivities(P＞0.05).With time elapsed,the VAS and ODI scores were significantly decreased in both groups(P＜0.05),whereas which were not statistically significant between the two groups at any time point accordingly(P＞0.05).With regard of imaging,the vertebral canal space oc-cupancy rate was significantly decreased(P＜0.05),whereas the vertebral space height and lumbar lordotic angle remained unchanged in both groups postoperatively compared with those preoperatively(P＞0.05),and there were no statistically significant differences in the above-mentioned image parameters between the two groups at any time points correspondingly(P＞0.05).[Conclusion]The targeted foraminoplas-ty with visual trephine in PTED does achieve satisfactory clinical consequence for lumbar disc prolapse,with advantages of meeting the de-mand properly,reducing the number of X-ray fluoroscopy,shortening the puncture catheterization time,reducing bleeding,declining intra-operative pain of patients,and improving the patient's intraoperative experience.
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