首页|超分子水凝胶促进软骨再生的研究现状

超分子水凝胶促进软骨再生的研究现状

Current researches on supramolecular hydrogel promoting cartilage regeneration

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软骨由于缺乏血管、神经和淋巴,导致软骨的再生能力有限.传统的临床治疗方法均不能达到满意的疗效,而组织工程技术为软骨损伤的修复提供了新的方向.目前,软骨再生研究取得了巨大进步,但骨软骨界面和全层关节软骨缺损的修复仍然具有挑战性.超分子水凝胶是一类通过水凝胶剂的非共价相互作用形成的自组装网络结构,具有可调节机械强度、剪切变稀、较强的自愈合能力、良好的生物相容性和可注射性等优点,能够有效促进软骨再生.本文就超分子水凝胶的特点、合成机制、软骨再生情况和应用不足的研究现状进行了综述.
Cartilage has limited capacity of regeneration due to its lack of blood vessels,nerves,and lymph.Traditional clinical treat-ment methods cannot achieve satisfactory curative effect,but tissue engineering technology provides a new direction for the repair of carti-lage damage.Currently,great progress has been made in cartilage regeneration,but the repair of osteochondral interface and full-thickness articular cartilage defects remains challenging.Supramolecular hydrogel is a kind of self-assembled network structures formed by non-co-valent interactions of hydrogels,which has the advantages of adjustable mechanical strength,shear thinning,strong self-healing ability,good biocompatibility and injectability.It can effectively promote cartilage regeneration due to its properties.In this paper,the characteris-tics,synthesis mechanism,cartilage regeneration and insufficient application of supramolecular hydrogels were reviewed.

supramolecular hydrogelcartilage regenerationbone marrow mesenchymal stem cells

刘永飞、曹建泽、张杰、赵海燕

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兰州大学第一临床医学院,甘肃兰州 730000

兰州大学第一医院骨科,甘肃兰州 730000

超分子水凝胶 软骨再生 骨髓间充质干细胞

国家自然科学基金项目甘肃省自然科学基金项目兰州市人才创新创业项目兰州大学第一医院院内基金项目

8206039420JR10RA6732020-RC-45ldyyyn2019-01

2024

中国矫形外科杂志
中国残疾人康复协会 中国人民解放军第八十八医院

中国矫形外科杂志

CSTPCD北大核心
影响因子:1.521
ISSN:1005-8478
年,卷(期):2024.32(4)
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