Cartilage has limited capacity of regeneration due to its lack of blood vessels,nerves,and lymph.Traditional clinical treat-ment methods cannot achieve satisfactory curative effect,but tissue engineering technology provides a new direction for the repair of carti-lage damage.Currently,great progress has been made in cartilage regeneration,but the repair of osteochondral interface and full-thickness articular cartilage defects remains challenging.Supramolecular hydrogel is a kind of self-assembled network structures formed by non-co-valent interactions of hydrogels,which has the advantages of adjustable mechanical strength,shear thinning,strong self-healing ability,good biocompatibility and injectability.It can effectively promote cartilage regeneration due to its properties.In this paper,the characteris-tics,synthesis mechanism,cartilage regeneration and insufficient application of supramolecular hydrogels were reviewed.