[Objective]To compare the clinical outcome of accurately targeted(AT)unilateral percutaneous vertebroplasty(PVP)versus the routine counterpart for osteoporotic vertebral compression fractures(OVCF).[Methods]A retrospective analysis was performed on 72 pa-tients who underwent PVP surgery for OVCF in our hospitals from January 2020 to June 2022.According to the surgeon-patient communica-tion,36 patients received the AT unilateral PVP,while other 36 patients received the routine unilateral PVP.Perioperative period,follow-up and imaging data of the two groups were compared.[Results]All patients in both groups got corresponding surgical operation completed smoothly without serious complications.The AT group was significantly less than the routine group in terms of operation time[(28.9±3.3)min vs(46.2±9.1)min,P＜0.001],intraoperative fluoroscopy times[(13.2±1.0)times vs(17.1±2.6)times,P＜0.001]and puncture needle adjust-ment times[(3.3±6.5)times vs(4.8±6.5)times,P＜0.001],while the former got significantly greater bone cement injection volume[(6.3±1.0)ml vs(5.6±0.9)ml,P＜0.001],with significantly better bone cement distribution than the latter[Ⅰ/Ⅱ/Ⅲ,(3/16/17)vs(8/22/6),P=0.004].There were no significant differences in bone cement leakage rate,walking time and hospital stay between the two groups(P＞0.05).As time elapsed in follow-up period lasted for(15.5±0.4)months,the VAS,ODI and JOA scores in both groups were significantly improved(P＜0.05),where-as which were not statistically significant between the two groups at any time points accordingly(P＞0.05).Regarding imaging,the anterior vertebral height and local kyphotic Cobb angle were significantly improved in both groups after surgery compared with those preoperatively(P＜0.05),while which were not statistically significant between the two groups at any matching time points(P＞0.05).[Conclusion]This ac-curately targeted unilateral percutaneous vertebroplasty achieves satisfactory consequence for osteoporotic vertebral compression fractures,with advantages of accurate puncture path,low intraoperative radiation exposure,minimized tissue damage,and sufficient bilateral bone ce-ment distribution,despite of a certain learning curve.
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