[Objective]To investigate the clinical efficacy of tibial tuberosity osteotomy combined with double-tunnel isometric recon-struction of medial patellofemoral ligament(MPFL)in the treatment of recurrent patellar dislocation.[Methods]A retrospective study was conducted on 20 patients who received surgical treatment for recurrent patellar dislocation in our hospital from May 2017 to May 2022.All of them underwent double-tunnel isometric reconstruction MPFL combined with tibial tuberosity osteotomy.The clinical and imaging data were evaluated.[Results]All the patients had operation performed successfully with operation time of(65.3±6.7)min,and were followed up for(12.2±0.7)months.Compared with those before operation,the Lysholm score[(53.7±9.9),(86.5±6.0),P<0.001],Kujala score[(55.5±6.3),(83.7±7.9),P<0.001]and IKDC scores[(54.6±8.7),(86.7±6.9),P<0.001]were significantly increased 12 months postoperatively.No further dislocation occurred in anyone of them utill the last follow-up.Radiographically,the patellofemoral congruence angle(PCA)[(28.2±4.4)°,(13.3±2.6)°,P<0.001],patella title angle(PTA)[(23.1±4.8)°,(8.9±2.9)°,P<0.001],tibial tubercle-trochlear groove distance(TT-TG)[(22.1± 1.74)mm,(11.9±1.9)mm,P<0.001]and quadricep angle(Q Angle)[(23.1±2.4)°,(15.1±2.6)°,P<0.001]decreased significantly 12 months after operation compared with those preoperatively,but the patellofemoral cartilage thickness remained unchanged(P>0.05).[Conclusion]The tibial tuberosity osteotomy combined with double-tunnel isometric reconstruction of MPFL is an effective treatment for recurrent patel-lar dislocation.