[Objective]To investigate the clinical outcomes of robot-assisted extrapedicular percutaneous kyphoplasty(PKP)for the treatment of osteoporotic vertebral compression fracture(OVCF).[Methods]A retrospective study was conducted on 43 patients who re-ceived extrapedicular PKP for OVCF from March 2019 to March 2022.According to the preoperative doctor-patient communication,18 cases underwent robot-assisted puncture(robot group),while other 25 cases underwent traditional fluoroscopy guided puncture(fluoroscopy group).The perioperative,follow-up and imaging data of the two groups were compared and analyzed.[Results]Although the robot group consumed significantly longer operative time than the fluoroscopy group[(43.5±5.2)min vs(26.2±4.9)min,P<0.001],the former was signifi-cantly less than the latter in term of intraoperative fluoroscopy number[(3.3±0.8)times vs(8.8±3.3)times,P<0.001].There were no signifi-cant differences in first puncture success rate,bone cement leakage rate,walking time and hospitalization days between the two groups(P>0.05).The mean follow-up time was(19.8±5.7)months,and there was no significant difference between the two groups in the time to return to full weight-bearing activities(P>0.05).The VAS and ODI scores were significantly decreased in both groups over time(P<0.05),which were not significantly different between the two groups at any corresponding time points(P>0.05).As for imaging,there was no significant difference in the excellence rate of bone cement distribution between the two group(P>0.05).The local kyphotic Cobb angle and the rela-tive anterior vertebral height significantly improved postoperatively compared with those preoperatively in both groups(P<0.05),whereas which proved not statistically significant between the two groups at any time points accordingly(P>0.05).[Conclusion]Robotic navigation can reduce the number of fluoroscopy,but increase the operation time,and can be a useful supplement to current surgical methods.