[Objective]To compare the clinical outcomes of percutaneous transforaminal endoscopy(PTE)versus unilateral biportal en-doscopy(UBE)for degenerative lumbar spinal stenosis(DLSS)in the elderly.[Methods]A retrospective research was done on 72 patients who received surgical decompression for single-segment DLSS from January 2020 to June 2022.Based on surgeon-patient discussion pre-operatively,37 patients underwent PTE,while other 35 patients received UBE.The perioperative,follow-up and imaging data of the two groups were compared.[Results]The PTE group proved significantly superior to the UBE group in terms of operating time[(63.2±11.0)min vs(81.2±10.3)min,P<0.001],total length of incision[(1.0±0.2)cm vs(2.5±0.3)cm,P<0.001],intraoperative blood loss[(39.2±10.9)ml vs(89.5±11.3)ml,P<0.001],postoperative walk time[(1.4±0.5)days vs(2.2±0.4)days,P<0.001],hospitalization time[(9.2±1.4)days vs(11.2± 2.1)days,P<0.001],and time to recover full weight-bearing activity[(62.2±9.5)days vs(71.1±10.2)days,P<0.001].The VASs for lower back pain and leg pain,as well as ODI scores were significantly decreased in both groups over time(P<0.05).The PTE group was signifi-cantly better than the UBE group a day postoperatively regarding to VAS score for back pain[(3.7±1.0)vs(4.3±1.1),P=0.018],VAS for leg pain[(2.9±0.5)vs(3.2±0.4),P=0.007],and ODI score[(26.6±7.7)vs(30.3±5.4),P=0.022],despite of that the differences in abovesaid scores between the two groups became not statistically significant since then(P>0.05).With respect of imaging,the canal area in both groups increased significantly postoperatively compared with those preoperatively(P<0.05),but which in both groups decreased again over time after surgery(P<0.05).At the last follow-up,PTE group was significantly inferior to the UBE group in canal aera[(126.3±25.4)cm2 vs(163.7±28.6)cm2,P<0.001].There were no statistically significant differences in intervertebral space height and lumbar lordosis between the two groups at any time points accordingly(P>0.05).[Conclusion]Both PTE and UBE can achieve good clinical efficacy in the treat-ment of DLSS.By comparison,PTE has benefits of less trauma,faster recovery,and less early postoperative low back pain and leg pain,but UBE get a wider range of decompression.