Blood vessels in bone tissue play an important role in bone growth,development,remodeling and injury repair.Type H ves-sels are a subtype of bone vessels with high expression of CD31 and Emcn,which have significant anatomical characteristics and age-de-pendent decline characteristics,and are deeply involved in the coupling between angiogenesis and bone formation.Some cellular mole-cules,such as hypoxia inducible factor-1,vascular endothelial growth factor-A,platelet derived growth factor-BB,and slit guidance ligand 3,are involved in regulating the formation of Type H vessels.Meanwhile,drugs therapy,physical therapy,and metastatic tumors can also af-fect Type H vessels.In this paper,the molecular mechanism and influencing factors of Type H vessels formation are reviewed based on the literatures in recent years,to provide a new idea for the diagnosis and treatment of bone diseases such as fracture nonunion and abnormal bone metabolism.
type H vesselsangiogenesisbone formationinfluencing factors
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