摘要
骨血管在骨生长、重塑和损伤修复中发挥重要作用,H型血管是一类同时高表达CD31与Emcn的骨血管亚型,具有显著的解剖特征与年龄依赖性减少特点,深度参与血管生成与骨形成之间的偶联.一些细胞因子如缺氧诱导因子1α、血管内皮生长因子A、血小板衍生生长因子BB、神经轴突导向因子3等可参与调控H型血管的生成,同时药物治疗、物理治疗和转移性肿瘤也能对H型血管产生影响.本文通过回顾近年文献,总结H型血管生成的分子机制与影响因素,以期为骨折不愈合、骨代谢异常等骨病的治疗提供新思考.
Abstract
Blood vessels in bone tissue play an important role in bone growth,development,remodeling and injury repair.Type H ves-sels are a subtype of bone vessels with high expression of CD31 and Emcn,which have significant anatomical characteristics and age-de-pendent decline characteristics,and are deeply involved in the coupling between angiogenesis and bone formation.Some cellular mole-cules,such as hypoxia inducible factor-1,vascular endothelial growth factor-A,platelet derived growth factor-BB,and slit guidance ligand 3,are involved in regulating the formation of Type H vessels.Meanwhile,drugs therapy,physical therapy,and metastatic tumors can also af-fect Type H vessels.In this paper,the molecular mechanism and influencing factors of Type H vessels formation are reviewed based on the literatures in recent years,to provide a new idea for the diagnosis and treatment of bone diseases such as fracture nonunion and abnormal bone metabolism.
基金项目
国家自然科学基金地区科学基金(82060396)
国家自然科学基金地区科学基金(82160809)
广西医科大学青年科学基金(GXMUYSF202233)
NETL
NSTL
万方数据