[Objective]To compare the clinical effect of multi-ligament reconstruction and repair with or without tourniquet for KD-Ⅲ-M knee dislocation.[Methods]A total of 27 patients with knee joint dislocation combined with multiple-ligament injuries admitted from January 2017 to January 2022 were randomly divided into two groups using a random number table.In the tourniquet group,13 pa-tients received multi-ligament reconstruction and repair underwent tourniquet,while in the non-tourniquet group,14 cases were operated on without tourniquet.The perioperative data and follow-up results were compared between the two groups.[Results]All patients in both groups were operated successfully without significant differences in terms of operation time,intraoperative blood loss,ambulation time after surgery,postoperative hospitalization days between the two groups(P<0.05).However,the non-tourniquet group had significantly lower postoperative drainage volume than the tourniquet group[(35.6±2.7)ml vs(72.2±3.3)ml,P<0001].The VAS scores significantly decrease,whereas the Lysholm and IKDC scores significantly increased in both groups over time postoperatively(P<0.05).The non-tourniquet group proved significantly superior to the tourniquet group in VAS score 1week after surgery[(4.4±0.8)vs(5.6±0.9),P=0.021],despite of the fact that it became not significant between the two groups latterly(P>0.05).There were no statistically significant differences in Lysholm and IK-DC scores between the two groups at any corresponding time points(P>0.05).[Conclusion]The multi-ligament reconstruction and repair for KD-Ⅲ-M dislocation of the knee achieve satisfactory clinical consequences,while the non-tourniquet operation has the advantages of less drainage and less early pain.