[Objective]To compare the clinical efficacy of posterior lumbar interbody fusion(PLIF)with unilateral versus bilateral pedi-cle screws fixations for lumbar degenerative diseases.[Methods]A retrospective study was done on 90 patients who received PLIF for lum-bar degenerative diseases in our hospital from August 2018 to June 2021.According to preoperative doctor-patient communication,48 pa-tients underwent unilateral fixation,while other 42 patients underwent bilateral fixations.The perioperative period,follow-up and imaging documents were compared between the two groups.[Results]The unilateral group proved significantly superior to the bilateral group in terms of operation time[(108.3±10.7)min vs(155.8±17.1)min,P＜0.05],intraoperative blood loss[(121.2±18.4)ml vs(186.7±18.3)ml,P＜0.05]and hospital stay[(10.2±3.4)days vs(11.8±3.7)days,P＜0.05],despite statistically insignificant differences in incision length,intraop-erative fluoroscopy times,walking time and incision healing grade between the two groups(P＞0.05).The average follow-up time was(29.1± 6.2)months,and there was no a significant difference between the two groups in the time to return to full weight-bearing activities(P＞0.05).The VAS scores of low back pain and leg pain,as well as ODI and JOA scores significantly improved in both groups over time(P＜0.05).At 6 months after surgery,the unilateral group was significantly better than the bilateral group regarding to ODI[(25.5±6.2)％vs(28.5±7.4)％,P＜0.05]and JOA scores[(20.5±2.2)vs(19.6±1.8),P＜0.05]regardless of insignificant difference in VAS score between the two groups(P＞0.05),whereas all abovesaid clinical scores became not statistically significant between the two groups at the last follow-up(P＞0.05).Radiological-ly,the vertebral space height and lordotic Cobb angle significantly improved in both groups at 6 months after surgery and at the last follow-up compared with those preoperatively(P＜0.05).However,there were no statistically significant differences in the above image indexes and fusion rate between the two groups at any time points correspondingly(P＞0.05).[Conclusion]The unilateral pedicle screw fixation PLIF does restore spinal stability,restore spinal function and reduce surgical injury in this study.
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