Research progress on pathogenesis of steroid-induced osteonecrosis of the femoral head
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激素诱导性股骨头坏死(steroid-induced osteonecrosis of the femoral head,SONFH)病理特征为骨细胞缺血、坏死、骨小梁断裂,股骨头塌陷.终末期SONFH临床表现为疼痛、关节功能障碍,是一类可致残的难治性骨科疾病.此病的发病机制错综复杂,常表现为多路径相互联合或交叉作用导致.本文对SONFH的发病机制及相关信号通路的研究进展进行综述,为进一步认识SONFH的发病机制及其防治研究提供帮助.
Steroid-induced osteonecrosis of the femoral head(SONFH)is a style of pathology characterized by osteocyte ischemia,ne-crosis and trabecular fracture and femoral head collapse.The end-stage SONFH with clinical manifestations of pain and joint dysfunction is a disabling and refractory orthopedic disease.This disorder has complex pathogenesis,often manifested by the combination or cross-action of multiple pathways.In this review,the pathogenesis and related signaling pathways of SONFH were reviewed in order to further understand the pathogenesis and prevention of SONFH.
femoral head necrosisglucocorticoidpathogenesisprevention and treatment
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