激素性股骨头坏死发病机制的研究进展
Research progress on pathogenesis of steroid-induced osteonecrosis of the femoral head
张杰 1曹建泽 1刘永飞 1赵海燕2
作者信息
- 1. 兰州大学第一临床医学院,甘肃兰州 730000
- 2. 兰州大学第一医院骨科,甘肃兰州 730000
- 折叠
摘要
激素诱导性股骨头坏死(steroid-induced osteonecrosis of the femoral head,SONFH)病理特征为骨细胞缺血、坏死、骨小梁断裂,股骨头塌陷.终末期SONFH临床表现为疼痛、关节功能障碍,是一类可致残的难治性骨科疾病.此病的发病机制错综复杂,常表现为多路径相互联合或交叉作用导致.本文对SONFH的发病机制及相关信号通路的研究进展进行综述,为进一步认识SONFH的发病机制及其防治研究提供帮助.
Abstract
Steroid-induced osteonecrosis of the femoral head(SONFH)is a style of pathology characterized by osteocyte ischemia,ne-crosis and trabecular fracture and femoral head collapse.The end-stage SONFH with clinical manifestations of pain and joint dysfunction is a disabling and refractory orthopedic disease.This disorder has complex pathogenesis,often manifested by the combination or cross-action of multiple pathways.In this review,the pathogenesis and related signaling pathways of SONFH were reviewed in order to further understand the pathogenesis and prevention of SONFH.
关键词
股骨头坏死/糖皮质激素/发病机制/防治Key words
femoral head necrosis/glucocorticoid/pathogenesis/prevention and treatment引用本文复制引用
基金项目
国家自然科学基金地区科学基金(82060394)
兰州市人才创新创业项目(2020-19095)
出版年
2024
NETL
NSTL
万方数据