[Objective]To introduce the surgical technique and preliminary clinical results of computer aided design(CAD)assisted cervicothoracic hemivertebrae resection and deformity correction.[Methods]From January 2016 to December 2020,14 patients with con-genital cervicothoracic hemivertebra malformations were treated with CAD assisted cervicothoracic hemivertebra resection and deformity correction.Mimics software was used to perform orthopedic design and simulate the orthopedic process before surgery.Under neuroelectro-physiological monitoring system used during surgery to ensure the safety of surgical correction,pedicle screws were precisely inserted accord-ing to the preoperative design,half vertebra was removed,and the scoliotic deformity was corrected by pedicle screw-rod system.The brace was worn after operation to maintain the correction effect.[Results]All patients were successfully operated,with no serious vascular,nerve and organ injuries and other complications.A total of 140 pedicle screws were inserted,with an accuracy of 97.1%.Compared with those pre-operatively,the cervicothoracic scoliotic angle[(53.9±17.9)°,(11.5±2.5)°,P<0.001],the kyphotic angle[(27.8±9.8)°,(10.7±1.6)°,P<0.001]significantly improved at the latest follow-up lasted for(35.5±13.2)months.In addition,the torticollis angle,T1 inclination and clavicular an-gle were significantly reduced postoperatively(P<0.05).No loss of correction,pseudoarthrosis and loosening of internal fixation occurred in anyone of them during follow-up.[Conclusion]The CAD assisted cervicothoracic hemivertebra resection and deformity correction are safe and effective to insert pedicle screws and complete hemivertebra resection accurately,and improve surgical efficiency.