[Objective]To compare the clinical efficacy of absorbable versus metal screws for internal fixation of Maisonneuve frac-tures.[Methods]A retrospective study was conducted on 31 patients who received surgical treatment for Maisonneuve fractures in our de-partment from January 2020 to October 2021.Based on preoperative surgeon-patient discussion,15 patients had internal fixation with ab-sorbable screws,while the remaining 16 patients were with metal screws.The perioperative,clinical and imaging documents were compared between the two groups.[Results]There were no significant differences in operation time,total incision length,intraoperative blood loss,in-traoperative fluoroscopy times,incision healing grade and hospital stay between the two groups(P>0.05).All patients in both groups were followed up for a mean of(19.2±4.6)months,and the absorbable group resumed full weight-bearing activity significantly earlier than the metal group[(70.4±8.6)days vs(84.6±5.6)days,P<0.001].As time went by,the AOFAS score and ankle dorsal-plantar flexion ROM in both groups increased significantly,while the VAS score decreased significantly(P<0.05).At 3 months after surgery,the absorbable group proved significantly superior to the metal group regarding ankle dorsal-plantar flexion ROM[(42.5±3.6)° vs(38.2±4.9)°,P=0.009],whereas which turned to be no significant difference between the two groups at 12 months after surgery and the last follow-up(P>0.05).In addition,there were no statistically significant differences in terms of AOFAS and VAS scores between the two groups at any time points accordingly(P>0.05).With respect to imaging,there was no statistically significant difference in postoperative fracture reduction quality between the two groups(P>0.05).Compared with those preoperatively,the medial clear space(MCS)and tibiofibular clear space(TFCS)in both groups significantly declined(P<0.05),while the tibiofibular overlap(TFO)increased significantly at the last follow-up(P<0.05),which proved not statistically significant between the two groups at any matching time points(P>0.05).At the last follow-up,all patients in both group got the injury healed well with on a statistically significant difference in healing time between them(P>0.05).[Conclusion]The absorbable screw fixation does achieve similar clinical consequence with the metal counterpart for Maisonneuve fracture,however,the former has advantages of early weight-bearing exercise and no need for secondary surgery to remove the implant over the latter.