[Objective]To explore the risk factors of poor incision healing after posterior pedicle screw fixation of thoracolumbar frac-tures.[Method]A total of 146 patients were included in this study,who underwent posterior pedicle screw fixation of thoracolumbar frac-tures in our hospital From June 2017 to September 2022.The patients were divided into two groups based on the condition of incision heal-ing:the poor incision healing group(PIH)and the good incision healing group(GIH).Univariate comparison and multivariate logistic regres-sion analysis were used to explore the risk factors for PIH.[Results]Among146 patients who underwent surgical treatment,21 had PIH,ac-counting for 14.4%.As results of univariate comparisons,the PIH groups proved significantly greater than the GIH group in terms of age[(47.8±8.1)years vs(41.3±11.2)years,P=0.003],BMI[(26.0±5.3)kg/m2 vs(21.1±3.4)kg/m2,P<0.001],history of diabetes[yes/no,(11/10)vs(10/115),P<0.001],operation time[(91.9±17.9)min vs(77.7±16.5)min,P<0.001],and the ratio of posterior internal fixation and simple minimally invasive internal fixation[fixation/open decompression fixation/minimally invasive fixation,(4/9/8)vs(76/18/31),P<0.001].The multivariate logistic regression analysis showed that diabetes(OR=4.017,P=0.030),BMI(OR=1.178,P=0.009),and operation time(OR=1.036,P=0.040)were independent risk factors for poor wound healing after posterior pedicle screw fixation of thoracolumbar fractures.[Conclusion]The longer operation time,greater BMI and diabetes are the main factors related to poor wound healing after posterior pedi-cle screw fixation of thoracolumbar fractures.