巨噬细胞极化在椎间盘退变的作用研究现状
Current research on role of macrophage polarization in intervertebral disc degeneration
王伟 1姜成 1黄春明 2李小川2
作者信息
- 1. 广东医科大学第一临床医学院,广东湛江 524023
- 2. 广东医科大学第一临床医学院,广东湛江 524023;高州市人民医院脊柱外科,广东高州 525232
- 折叠
摘要
持续性的下腰背部疼痛(low back pain,LBP)是人们求医以及导致残疾的主要原因,导致了巨大的医疗负担.腰椎间盘(intervertebral disc,IVD)退变、背根神经节、肌肉等脊柱组织结构和功能异常可诱发或加重LBP,其中椎间盘退变被认为是引起LBP最重要的因素,而年龄又是IVD退变的关键因素,因为衰老会加剧椎间盘退变和疾病的进展.有研究表明,巨噬细胞在人和啮齿动物退变的IVD中都有浸润,且巨噬细胞的数量与椎间盘退变程度呈正相关.本文综述了目前巨噬细胞极化在椎间盘衰老退变中的研究现状,了解椎间盘衰老的潜在机制,以利于延缓或改善年龄依赖性退化进程,为临床预防和治疗LBP提供参考.
Abstract
Persistent low back pain(LBP)is the leading cause of health care and disability,resulting in a significant health care burden.Intervertebral disc(IVD)degeneration,dorsal root ganglion,muscle and other spinal tissue structure and function abnormalities can induce or aggravate LBP,among which disc degeneration is considered to be the most important factor causing LBP,while age is also the key factor of IVD degeneration because aging increases disc degeneration and disease progression.Studies have shown that macrophages are infiltrated in both human and rodent degraded IVDs,and the number of macrophages is positively correlated with the degree of disc degeneration.This article reviewed the current research status of macrophage polarization in intervertebral disc aging and degeneration,to understand the poten-tial mechanism of intervertebral disc aging,in order to help delay or decrease the age-dependent degeneration process,and provide referenc-es for clinical prevention and treatment of LBP.
关键词
巨噬细胞极化/椎间盘/衰老/炎症因子Key words
macrophage polarization/intervertebral disc/senescence/inflammatory factors引用本文复制引用
基金项目
国家自然科学基金(81802130)
中国博士后科学基金(2018M630968)
出版年
2024
NETL
NSTL
万方数据