Diagnostic significance of neutrophil extracellular traps for postoperative pneumonia in elderly patients with hip fracture/
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NETL
NSTL
万方数据
[目的]探讨外周血中性粒细胞胞外陷阱(neutrophil extracellular traps,NETs)含量对老年髋部骨折患者术后肺炎的诊断价值.[方法]前瞻性选取2019年1月-2022年2月在本院进行手术治疗的57例老年髋部骨折患者,观察其术后是否发生肺炎.采用单项因素比较和逻辑回归分析探讨术后肺炎的危险因素;并评价危险因素预测术后肺炎的诊断价值.[结果]57例患者中,发生肺炎19例,占33.3％;未发生肺炎38例,占66.7％.单因素比较表明:肺炎组代表NETs的外周血浆髓过氧化物酶-脱氧核糖核酸(myeloperoxidase-deoxyribonucleic acid,MPO-DNA)[(6.5±2.0)ng/ml vs(3.6±0.7)ng/ml,P＜0.05]、中性/淋巴细胞比(neutrophil to lymphocyte ratio,NLR)[(6.7±1.9)vs(5.8±0.9),P＜0.05]和中性/淋巴和血小板比(neutro-phil to lymphocyte and platelet ratio,N/LPR)[(6.7±2.0)vs(5.4±0.8),P＜0.05]均显著高于非肺炎组;而两组间中性白细胞、淋巴细胞和血小板差异均无统计学意义(P＞0.05).逻辑回归分析显示:外周血NETs(OR=7.289,95％CI 1.980～26.836,P＜0.05)和NLPR(OR=2.087,95％CI 1.005～4.333,P＜0.05)为术后肺炎发生的独立危险因素.受试者工作特征(ROC)分析显示,外周血NETs预判术后肺炎的曲线下面积(area under curve,AUC)为0.892.最佳截断值为4.2,灵敏度为84.2％,特异度为76.3％.亚组分析显示,外周血MPO-DNA含量≥4.2组患者术后肺炎发生率显著高于NETs含量＜4.2组(64.0％rs 9.4％,P＜0.05).[结论]术后外周血NETs含量升高是老年髋部骨折患者术后肺炎的危险因素,监测外周血NETs含量对老年髋部骨折患者术后肺炎的防治有意义.
[Objective]To investigate the diagnostic value of neutrophil extracellular traps(NETs)in peripheral blood for postoperative pneumonia in elderly patients with hip fracture.[Methods]A prospective study was conducted on 57 elderly patients who underwent surgi-cal treatments for hip fracture in our hospitals from January 2019 to February 2022.Based on whether pneumonia developed after surgery,the patients were divided into two groups,and univariate comparison and logistic regression analysis were performed to search the indepen-dent risk factor of pneumonia.Furthermore,significance of the risk factors used for predicting postoperative pneumonia was evaluated.[Re-sults]Among the 57 patients,19 patients(33.3％)were diagnosed with pneumonia,while the remaining 38 patients(66.7％)were of non-pneumonia.Regarding univariate comparison,the pneumonia group was significantly greater than the non-pneumonia group in terms of blood plasma myeloperoxidase-deoxyribonucleic acid(MPO-DNA)that represented NETs[(6.5±2.0)ng/ml vs(3.6±0.7)ng/ml,P＜0.05],neutrophil to lymphocyte ratio(NLR)[(6.7±1.9)vs(5.8±0.9),P＜0.05]and neutrophil to lymphocyte and platelet ratio(N/LPR)[(6.7±2.0)vs(5.4±0.8),P＜0.05],although there were no significant differences in neutrophils,lymphocytes and platelets between the two groups(P＞0.05).As results of logistic regression analysis,the peripheral blood NETs(OR=7.289,95％CI 1.980～26.836,P＜0.05)and N/LPR(OR=2.087,95％CI 1.005～4.333,P＜0.05)were independent risk factors for postoperative pneumonia.Receiver operating characteristic(ROC)analysis showed that peripheral blood NETs predicted postoperative pneumonia with an area under curve(AUC)of 0.892,optimal cut-off of 4.2,sensitivity of 84.2％,and specificity of 76.3％.Subgroup analysis showed that the incidence of postoperative pneumonia in patients with peripheral blood NETs ≥4.2 was significantly higher than that in NETs content＜4.2 group(64.00％vs 9.4％,P＜0.05).[Conclusion]The increased content of NETs in peripheral blood is a risk factor for postoperative pneumonia in elderly patients with hip fracture.Monitor-ing the content of NETs in peripheral blood is significant for the prevention and treatment of postoperative pneumonia in elderly patients with hip fracture.
NETL
NSTL
万方数据
