警报素在椎间盘退变中作用的研究进展
Research progress on the role of alarmins in intervertebral disc degeneration
罗章斌 1邱晓明 1张亦智 1康学文1
作者信息
- 1. 兰州大学第二医院骨科,甘肃兰州 730030
- 折叠
摘要
椎间盘退变(intervertebral disc degeneration,IVDD)是一类骨科常见的疾病,给社会经济和人体健康造成了巨大的负担.目前,椎间盘退变的治疗手段仅能缓解患者症状,无法阻止椎间盘退变的进程.炎症反应是椎间盘退变的重要原因之一.损伤相关分子模式(damage-associated molecular pattern,DAMP)是体内重要的一种免疫应答方式,警报素作为DAMP的配体,是一类在炎症反应中发挥重要功能的分子.警报素包括高迁移率族蛋白B1(high mobility group box-1 protein,HMGB1)、热休克蛋白(heat shock protein,HSP)、S100 蛋白家族、白细胞介素-1α(interleukin-1α,IL-1α)和白细胞介素-33(interleukin-33,IL-33)等蛋白,在机体应对外界引起的炎症反应、免疫应答过程中起着重要的作用.本文以不同警报素在椎间盘退变的作用及机制进行综述,以期为后续研究提供参考.
Abstract
Intervertebral disc degeneration(IVDD)is a prevalent orthopedic condition that imposes a significant burden on both the so-cial economy and human health.Currently,treatments for IVDD can only relieve patients'symptoms but cannot stop the process of disc de-generation.Inflammation stands as one of the key contributors to intervertebral disc degeneration,while damage-associated molecular pat-tern(DAMP)represents an essential immune response mechanism in vivo.Alarmin,as a ligand of DAMP,is a class of molecules that play an important role in inflammatory response.Alarmins encompass high mobility group box-1 protein(HMGB1),heat shock proteins(HSPs),S100 protein family,interleukin-1α(IL-1α),and interleukin-33(IL-33).This review aims to explore the effects and mechanisms of differ-ent alarmins on intervertebral disc degeneration,providing valuable references for future studies.
关键词
高迁移率族蛋白B1/热休克蛋白/髓核/椎间盘退变Key words
high mobility group box-1 protein/heat shock protein/nucleus pulposus/intervertebral disc degeneration引用本文复制引用
基金项目
国家自然科学基金项目(82272536)
兰州大学医学教育创新发展项目(lzuyxcx-2022-190)
出版年
2024
NETL
NSTL
万方数据