Ischemic stroke is one of the rare,but serious complications after hip arthroplasty.It has a high disability rate,and is life-threatening in severe cases.Its pathogenesis is closely related to traumatic inflammation and thrombosis.Recent studies have found that neu-trophil extracellular traps(NETs)are involved in the formation of arterial thrombosis.After hip arthroplasty,neutrophils are activated by in-flammation and platelet activation,inducing the production and release of NETs,keeping blood in a hypercoagulable state,efficiently aggre-gating platelets,promoting thrombin production,activating part of coagulation factors,and reducing the stability of atherosclerotic plaques,leading to ischemic stroke after surgery.The detection of NETs related biomarkers can predict the occurrence of postoperative ischemic stroke,inhibit the production or promote the degradation of NETs,and provide a new direction for the prevention and treatment of postopera-tive ischemic stroke,and provide a new idea for the development of new drugs.
NETL
NSTL
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