Low back pain is a common degenerative disease of the spine that has developed to be a serious social problem.Recent stud-ies have shown that intervertebral disc degeneration(IDD)is the primary cause of low back pain,whereas inhibiting IDD is an important tar-get for preventing and treating LBP.Causes of IDD include ageing,genetics,mechanical stress,and nutritional deficiencies.In recent years,an increasing number of studies have reported IDD caused by mechanical stress(MS),but the exact mechanism is still unclear.This paper in-tends to review the mechanisms of MS-induced IDD and provide theoretical references for clinical prevention and treatment of low back pain.
low back painintervertebral discintervertebral disc degenerationmechanical stressdirect damagesecondary damage
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